Last update
3/15/2026
Reviewed By
Overview
SCIENTIFIC SCORE
Questionable
Based on 16 Researches
6.8
USERS' SCORE
Good
Based on 3 Reviews
8.5
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Proprietary Probiotic Blend
134 mg (1 Billion CFU§)
†
Lactobacillus rhamnosus (GR-1®)
Lactobacillus reuteri (RC-14®)
Top Medical Research Studies
9
Lactobacillus reduces cold incidences
We evaluated the effectiveness of Lactobacillus casei strain Shirota in reducing upper respiratory tract infections (URTIs) among healthy middle-aged office workers. Over 12 weeks, 96 male participants consumed either fermented milk with LcS or a control milk.
Our findings showed a significant reduction in URTI episodes in those consuming the fermented milk—only 22.4% experienced infections compared to 53.2% in the control group. Furthermore, they had shorter illness durations and better immune responses. Overall, it seems that this daily intake can effectively reduce colds in healthy adults.
Our findings showed a significant reduction in URTI episodes in those consuming the fermented milk—only 22.4% experienced infections compared to 53.2% in the control group. Furthermore, they had shorter illness durations and better immune responses. Overall, it seems that this daily intake can effectively reduce colds in healthy adults.
Read More
8
We explored the effects of GCL1815, a lactic acid bacterium, on preventing common colds in a double-blind, randomized study with 200 participants.
Those taking GCL1815 experienced fewer symptoms like fever, fatigue, and nasal congestion compared to the placebo group.
The study suggests that GCL1815 activates dendritic cells, potentially enhancing our immune response to viruses. Overall, it appears that GCL1815 could be a promising aid for reducing common cold incidences in healthy adults.
Those taking GCL1815 experienced fewer symptoms like fever, fatigue, and nasal congestion compared to the placebo group.
The study suggests that GCL1815 activates dendritic cells, potentially enhancing our immune response to viruses. Overall, it appears that GCL1815 could be a promising aid for reducing common cold incidences in healthy adults.
Read More
8
Lactobacillus improves cold symptoms
We explored the effects of LG2055, a type of lactobacillus, on common cold symptoms in a study involving 200 healthy adults. Participants took either a yogurt containing LG2055 or a placebo for 12 weeks while completing daily health surveys.
The findings were promising; those consuming LG2055 reported fewer cold symptoms and showed improved immune markers. This suggests that incorporating LG2055 may help keep us feeling well during cold season by boosting our immune system.
The findings were promising; those consuming LG2055 reported fewer cold symptoms and showed improved immune markers. This suggests that incorporating LG2055 may help keep us feeling well during cold season by boosting our immune system.
Read More
Most Useful Reviews
9
Inflammation reduction
3 people found this helpful
This product has been quite helpful for menopausal itching. After taking it, I noticed marked improvements. I opted out of prescribed treatments and, after a week, my examination showed no inflammation. I felt much more comfortable and recommend it to others with similar concerns.
Read More
9
Rash improvement
Excellent! My rash has disappeared.
Read More
7.5
Helped after birth
6 people found this helpful
After giving birth, I experienced repeated itching and rashes, but since taking this product, I’ve noticed a significant reduction in symptoms. I’m grateful to find such supplements on iHerb, as they are scarce in Japan.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 16 Researches
6.8
- All Researches
9
Lactobacillus reduces cold incidences
We evaluated the effectiveness of Lactobacillus casei strain Shirota in reducing upper respiratory tract infections (URTIs) among healthy middle-aged office workers. Over 12 weeks, 96 male participants consumed either fermented milk with LcS or a control milk.
Our findings showed a significant reduction in URTI episodes in those consuming the fermented milk—only 22.4% experienced infections compared to 53.2% in the control group. Furthermore, they had shorter illness durations and better immune responses. Overall, it seems that this daily intake can effectively reduce colds in healthy adults.
Our findings showed a significant reduction in URTI episodes in those consuming the fermented milk—only 22.4% experienced infections compared to 53.2% in the control group. Furthermore, they had shorter illness durations and better immune responses. Overall, it seems that this daily intake can effectively reduce colds in healthy adults.
Read More
8
We explored the effects of GCL1815, a lactic acid bacterium, on preventing common colds in a double-blind, randomized study with 200 participants.
Those taking GCL1815 experienced fewer symptoms like fever, fatigue, and nasal congestion compared to the placebo group.
The study suggests that GCL1815 activates dendritic cells, potentially enhancing our immune response to viruses. Overall, it appears that GCL1815 could be a promising aid for reducing common cold incidences in healthy adults.
Those taking GCL1815 experienced fewer symptoms like fever, fatigue, and nasal congestion compared to the placebo group.
The study suggests that GCL1815 activates dendritic cells, potentially enhancing our immune response to viruses. Overall, it appears that GCL1815 could be a promising aid for reducing common cold incidences in healthy adults.
Read More
8
Lactobacillus shows promise for colds
We examined how SBT2055, a lactobacillus treatment, impacts common cold symptoms in healthy adults. In a thorough randomized, double-blind, placebo-controlled trial with 200 participants, those taking SBT2055 reported improved symptom relief compared to the placebo group.
Participants experienced less runny nose, plugged nose, sneezing, sore throat, and chill. This suggests that lactobacillus can enhance immune response, especially in individuals with weakened immunity. Our findings reveal potential benefits of lactobacillus for those suffering from common cold symptoms.
Participants experienced less runny nose, plugged nose, sneezing, sore throat, and chill. This suggests that lactobacillus can enhance immune response, especially in individuals with weakened immunity. Our findings reveal potential benefits of lactobacillus for those suffering from common cold symptoms.
Read More
8
We explored the impact of yogurt fermented with OLL1073R-1 on immunity against seasonal influenza. Through two controlled trials, we found that participants consuming the yogurt showed higher antibody levels to flu viruses compared to those taking a placebo. Notably, those who consumed the yogurt also reported fewer days of respiratory issues like throat soreness and colds.
This suggests that regular intake of this yogurt can potentially enhance our immune response to influenza vaccines and decrease the duration of cold-like symptoms.
This suggests that regular intake of this yogurt can potentially enhance our immune response to influenza vaccines and decrease the duration of cold-like symptoms.
Read More
8
Lactobacillus improves cold symptoms
We explored the effects of LG2055, a type of lactobacillus, on common cold symptoms in a study involving 200 healthy adults. Participants took either a yogurt containing LG2055 or a placebo for 12 weeks while completing daily health surveys.
The findings were promising; those consuming LG2055 reported fewer cold symptoms and showed improved immune markers. This suggests that incorporating LG2055 may help keep us feeling well during cold season by boosting our immune system.
The findings were promising; those consuming LG2055 reported fewer cold symptoms and showed improved immune markers. This suggests that incorporating LG2055 may help keep us feeling well during cold season by boosting our immune system.
Read More
User Reviews
USERS' SCORE
Good
Based on 3 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
9
Inflammation reduction
3 people found this helpful
This product has been quite helpful for menopausal itching. After taking it, I noticed marked improvements. I opted out of prescribed treatments and, after a week, my examination showed no inflammation. I felt much more comfortable and recommend it to others with similar concerns.
Read More
9
Rash improvement
Excellent! My rash has disappeared.
Read More
7.5
Helped after birth
6 people found this helpful
After giving birth, I experienced repeated itching and rashes, but since taking this product, I’ve noticed a significant reduction in symptoms. I’m grateful to find such supplements on iHerb, as they are scarce in Japan.
Read More
Frequently Asked Questions
9
Inflammation reduction
3 people found this helpful
This product has been quite helpful for menopausal itching. After taking it, I noticed marked improvements. I opted out of prescribed treatments and, after a week, my examination showed no inflammation. I felt much more comfortable and recommend it to others with similar concerns.
8
We explored the effects of GCL1815, a lactic acid bacterium, on preventing common colds in a double-blind, randomized study with 200 participants.
Those taking GCL1815 experienced fewer symptoms like fever, fatigue, and nasal congestion compared to the placebo group.
The study suggests that GCL1815 activates dendritic cells, potentially enhancing our immune response to viruses. Overall, it appears that GCL1815 could be a promising aid for reducing common cold incidences in healthy adults.
Those taking GCL1815 experienced fewer symptoms like fever, fatigue, and nasal congestion compared to the placebo group.
The study suggests that GCL1815 activates dendritic cells, potentially enhancing our immune response to viruses. Overall, it appears that GCL1815 could be a promising aid for reducing common cold incidences in healthy adults.
7
We explored how Lactobacillus rhamnosus affects the response of nasal epithelial cells to rhinovirus, the virus responsible for the common cold.
In our study, nasal cells from healthy adults were treated with different strains of L. rhamnosus before being infected with rhinovirus.
While L. rhamnosus did not alter viral replication or the production of certain inflammatory responses, it did reduce the secretion of pro-inflammatory mediators after infection.
Overall, while it may not stop the virus, L. rhamnosus seems to help dampen some of the cold's inflammatory effects.
In our study, nasal cells from healthy adults were treated with different strains of L. rhamnosus before being infected with rhinovirus.
While L. rhamnosus did not alter viral replication or the production of certain inflammatory responses, it did reduce the secretion of pro-inflammatory mediators after infection.
Overall, while it may not stop the virus, L. rhamnosus seems to help dampen some of the cold's inflammatory effects.
9
Lactobacillus reduces cold incidences
We evaluated the effectiveness of Lactobacillus casei strain Shirota in reducing upper respiratory tract infections (URTIs) among healthy middle-aged office workers. Over 12 weeks, 96 male participants consumed either fermented milk with LcS or a control milk.
Our findings showed a significant reduction in URTI episodes in those consuming the fermented milk—only 22.4% experienced infections compared to 53.2% in the control group. Furthermore, they had shorter illness durations and better immune responses. Overall, it seems that this daily intake can effectively reduce colds in healthy adults.
Our findings showed a significant reduction in URTI episodes in those consuming the fermented milk—only 22.4% experienced infections compared to 53.2% in the control group. Furthermore, they had shorter illness durations and better immune responses. Overall, it seems that this daily intake can effectively reduce colds in healthy adults.
References
- Watanabe I, Suzuki N, Takara T. Supplementation with heat-sterilized Lactobacillus crispatus strain KT-11 stimulates the T cell-related immune function of healthy Japanese adults: A pilot randomized, placebo-controlled, double-blind, parallel-group study. Nutr Res. 2025;134:99. 10.1016/j.nutres.2024.12.004
- Wada H, Mawatari T, Saito Y, Azuma N, Iwama Y. Induces Two Types of Dendritic Cell Activation and Effectively Suppresses Onset of the Common Cold: A Randomized, Double-Blind, Placebo-Controlled Trial. Nutrients. 2024;17. 10.3390/nu17010101
- Yarlagadda T, Zhu Y, Snape N, Carey A, Bryan E, et al. Lactobacillus rhamnosus dampens cytokine and chemokine secretion from primary human nasal epithelial cells infected with rhinovirus. J Appl Microbiol. 2024;135. 10.1093/jambio/lxae018
- Kobatake E, Iwama Y, Arai T, Tsukisaka Y, Kabuki T. SBT2055 Activates Plasmacytoid Dendritic Cells and Improves Subjective Symptoms of Common Cold in Healthy Adults: A Randomized, Double-Blind, Placebo-Controlled Parallel-Group Comparative Trial. Nutrients. 2023;15. 10.3390/nu15204458
- Hemmi J, Makino S, Yokoo T, Kano H, Asami Y, et al. Consumption of yogurt fermented with ssp. OLL1073R-1 augments serum antibody titers against seasonal influenza vaccine in healthy adults. Biosci Microbiota Food Health. 2023;42:73. 10.12938/bmfh.2022-037
- Kobatake E, Iwama Y, Arai T, Shioya N, Kise M, et al. Intake of SBT2055 improves subjective symptoms of common cold during winter season in healthy adults: A randomized, double-blind, placebo-controlled parallel-group comparative study. Front Nutr. 2022;9:1063584. 10.3389/fnut.2022.1063584
- Gelardi M, La Mantia I, Drago L, Meroni G, Aragona SE, et al. A probiotic mixture in patients with upper respiratory diseases: the point of view of the otorhinolaringologist. J Biol Regul Homeost Agents. 2020;34:5. PubMed
- Lazou Ahrén I, Berggren A, Teixeira C, Martinsson Niskanen T, Larsson N. Evaluation of the efficacy of Lactobacillus plantarum HEAL9 and Lactobacillus paracasei 8700:2 on aspects of common cold infections in children attending day care: a randomised, double-blind, placebo-controlled clinical study. Eur J Nutr. 2020;59:409. 10.1007/s00394-019-02137-8
- Murata M, Kondo J, Iwabuchi N, Takahashi S, Yamauchi K, et al. Effects of paraprobiotic MCC1849 supplementation on symptoms of the common cold and mood states in healthy adults. Benef Microbes. 2018;9:855. 10.3920/BM2017.0197
- Zhang H, Yeh C, Jin Z, Ding L, Liu BY, et al. Prospective study of probiotic supplementation results in immune stimulation and improvement of upper respiratory infection rate. Synth Syst Biotechnol. 2018;3:113. 10.1016/j.synbio.2018.03.001
- Gleeson M, Bishop NC, Struszczak L. Effects of Lactobacillus casei Shirota ingestion on common cold infection and herpes virus antibodies in endurance athletes: a placebo-controlled, randomized trial. Eur J Appl Physiol. 2016;116:1555. 10.1007/s00421-016-3415-x
- Makino S, Sato A, Goto A, Nakamura M, Ogawa M, et al. Enhanced natural killer cell activation by exopolysaccharides derived from yogurt fermented with Lactobacillus delbrueckii ssp. bulgaricus OLL1073R-1. J Dairy Sci. 2016;99:915. 10.3168/jds.2015-10376
- Shida K, Sato T, Iizuka R, Hoshi R, Watanabe O, et al. Daily intake of fermented milk with Lactobacillus casei strain Shirota reduces the incidence and duration of upper respiratory tract infections in healthy middle-aged office workers. Eur J Nutr. 2017;56:45. 10.1007/s00394-015-1056-1
- Kumpu M, Kekkonen RA, Korpela R, Tynkkynen S, Järvenpää S, et al. Effect of live and inactivated Lactobacillus rhamnosus GG on experimentally induced rhinovirus colds: randomised, double blind, placebo-controlled pilot trial. Benef Microbes. 2015;6:631. 10.3920/BM2014.0164
- Lehtoranta L, Kalima K, He L, Lappalainen M, Roivainen M, et al. Specific probiotics and virological findings in symptomatic conscripts attending military service in Finland. J Clin Virol. 2014;60:276. 10.1016/j.jcv.2014.03.021
- King S, Glanville J, Sanders ME, Fitzgerald A, Varley D. Effectiveness of probiotics on the duration of illness in healthy children and adults who develop common acute respiratory infectious conditions: a systematic review and meta-analysis. Br J Nutr. 2014;112:41. 10.1017/S0007114514000075
Data last updated:
